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Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis

There is also some evidence suggesting that high doses of B12 may lead to negative health outcomes in those with diabetes or kidney disease

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10.1186/s12974-018-1235-0 37 DiceJ

Compared with other studies, the metformin dose used in the present work had no detectable toxic effects in the animals ( Metabolic and Biometric Parameters Under ketamine and xylazine anesthesia (3 and 0.6 mg/100 g bw, respectively), a silicone cannula was implanted into the right jugular vein of the animals from both groups and stabilized on the dorsal region of the neck