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Yes, B12 supplements can help alleviate skin problems caused by deficiency

Plant Growth Regul 75(1):187197

Importantly, glutathione levels have been found to be depleted in the brain of MS patients (8, 9)

Second, it is essential for Phase II liver detoxification, the process where your liver conjugates (binds) used hormones and environmental chemicals to make them water-soluble so the body can excrete them through bile, urine, and sweat